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Moreover, as canonical Wnts are not generally found to activate PKA, phosphorylation at S675 is likely mediated by upstream signals that “cross-talk” with β-catenin signaling at this site
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Induction of this biosynthetic pathway enhances intracellular GSH levels and promotes cancer cell resistance to ferroptosis, 142,143 whereas pharmacological inhibition of GSH synthesis by L-buthionine-(S,R)-sulfoximine (BSO), a GCL inhibitor, induces ferroptosis 144
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