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This means two different things must happen for an orally administered peptide to achieve meaningful systemic exposure: the peptide needs to remain sufficiently intact through the gastrointestinal tract, and enough of that intact peptide then needs to cross the intestinal barrier
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Under the action of acetyl coenzyme A synthetase long chain family member 4 (ACSL4), PUFAs bind to CoA and are esterified and inserted into the cell membrane by lysophosphatidylcholine acyltransferase 3 (LPCAT3)
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