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In mice, a diet high in trimethylamine N-oxide (TMAO) increases liver lipid peroxidation, as indicated by higher malondialdehyde (MDA) and non-esterified fatty acids (NEFA) levels, and reduces antioxidant enzyme activities like total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px), disrupting liver lipid metabolism and causing oxidative stress damage [52]
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