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In contrast, the EST group displayed severe hepatic damage, including degeneration of hepatocytes, multinucleated giant cells, marked cytoplasmic vacuolation, atrophy, moderate fibrosis, prominent inflammatory infiltration, and extensive necrosis (Fig
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Topical NSAIDs (such as ibuprofen gel) offer localised pain relief with minimal systemic absorption and are recommended by NICE as first-line for localised joint pain
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