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The FDA's 2024 review discussed free-base and acetate forms but did not set a standard acetic-acid mixing instruction

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In contrast, lower than normal [ 14 C]-propionate or [ 14 C]- N 5 -methyl-tetrahydrofolate incorporation after fusion of cell lines with polyethylenglycol confirms that the two patients possess the same genetic defect (Watkins and Rosenblatt, 2013)