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Among the newer TKIs, abrocitinib, baricitinib, ritcletinib, and upadacitinib all have boxed warnings for serious infections, thrombosis, and major adverse cardiovascular events ( Cardiovascular events are associated specifically with JAK inhibitors, which may be related to slower cholesterol ester breakdown (Wei et al., 2023)
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doi: 10.3390/cells9102314
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