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Metabolic acidosis in Pyruvate Dehydrogenase (PDH) deficiency reflects a fundamental block in oxidative metabolism. Normally, the PDH complex converts pyruvate into acetyl‑CoA, linking glycolysis to the TCA cycle. When this pathway is
Uruno A, Matsumaru D, Ryoke R, Saito R, Kadoguchi S, Saigusa D, Saito T, Saido TC, Kawashima R, Yamamoto M
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