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Further, targeted metabolomics and isotope tracing experiments uncovered GGCT as a metabolic orchestrator to prioritize Gln to GSH flux for antioxidant defense, while activating glucose (Glc)-fueled anaplerosis to replenish TCA intermediates to fuel proliferation
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The construct efficiently crossed the BBB, selectively downregulated ADK in reactive A1 astrocytes, restored endogenous adenosine levels, suppressed aberrant mossy fiber sprouting and pathological circuit reorganization, and thereby reduced seizure frequency (Fig
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