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Metabolic engineering for optimized CAR-T cell therapy | Nature Metabolism
95% CI 1.050-1.335
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SIZE:100mg
Our results uncover a new noncanonical function of PKM2 as a transcriptional coactivator of Nrf2, which cooperates with its metabolic function to divert glucose flux into the pentose phosphate pathway 55 and thereby generates sufficient GSH for ROS detoxification
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