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BoNT/X protease cleaves VAMP1 between Arg 68 and Ala 69, and notable de-enrichment at Ala 69 and Asp 70, along with slight de-enrichment at Arg 68 in the substrate profile, suggests that P1, P1′ and P2′ primarily dictate BoNT/X protease substrate recognition (Fig
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Yasuda-Yoshihara et al., Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer
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