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Notably, in hepatocellular carcinoma it has been found that MALAT1 binds the mtDNA modifying the mitochondrial structure, reducing oxidative phosphorylation and ATP production, decreasing mtDNA copy number, and activating the apoptosis ( Figure 2 reports a brief overview of mitochondrial epigenetics in cardiovascular diseases

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Injectable or systemic use is considered more experimental, so any long-term plan should be discussed with a licensed medical provider.