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Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and Tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes
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Based on prior reports linking mitochondrial protein stability to a short fragment within the cyclic structural domain of SLC25A39 (amino acids 72–86) that mediates glutathione (GSH) response and recruits SLC25A39 to AFG3L2 for proteolysis, we generated a deletion mutant lacking this fragment (∆aa72-86), confirmed by Sanger sequencing (Fig
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