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News & Blogs » Antibody Drug Development News » The combination of CDK4/6 inhibitor and PD-1/PD-L1 immune checkpoint blocker is expected to enhance treatment efficacy Targeted immune checkpoint protein PD1 (programmed cell death protein 1) and its ligand PD-L1 have been approved in the treatment of several cancers, and multiple drugs can be seen on the market, including “broad-spectrum anticancer drugs” such as Keytruda (anti-PD1) from MSD, Opdivo (anti-PD1) from Bristol-Myers Squibb, Bavencio (anti-PD1) co-developed by Pfizer and Merck, Tecentriq (anti-PD-L1) from Roche and Imfinzi (anti-PD-L1) from Astra Zeneca
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Clinically, by monitoring the dynamic changes in biomarkers following natural product interventions, physicians can not only objectively evaluate the comprehensive regulatory effects of drugs on tumor metabolism, apoptosis, and immunity but also identify patient populations sensitive to specific natural products based on “reverse‐guided” biomarker discovery, thereby achieving true personalized treatment
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