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To apply this methodology to the anti-Met macrocycles, we designed precursor macrocycles bearing a short peptide motif containing a Cys residue at the C terminus and modified the sulfhydryl group with three bis-maleimide cross-linkers with different lengths, C6, PEG3 and PEG11 (Supplementary Table 2)

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In fact, FDA’s concern illustrates precisely why the distinction matters: ingredients manufactured to dietary-supplement specifications are not necessarily appropriate for sterile injectable drug products