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Surprisingly, although the NADPH level increased, the ROS level actually decreased in the presence of CITR in CF cells, suggesting that the increase in NADPH level in the presence of CITR was not able to accelerate NOX activity, thus confirming the hypothesis that the point at which the glycolytic flow is blocked—by CITR—is crucial for the regulation of cell redox status in CF

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However, HPV infection alone is not enough to cause malignant transformation