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Approximately 10 years following its discovery, substantial progress has been made concerning studies on ferroptosis, including the characterization of core molecular marks and regulatory components, such as glutathione peroxidase (GPX)4, solute carrier family 7 member 11 (SLC7A11), ferroptosis suppressor protein 1 (FSP1, also known as AIFM2), nuclear factor erythroid 2-related factor 2 (Nrf2) and p53, the identification of inducers, such as erastin, FINO2, RAS-selective lethal 3 (RSL3) and FIN56, and specific inhibitors ferrostatin-1, liproxstatin-1 and deferoxamine, which have together strengthened the fundamental understanding of ferroptotic cell death (11,12)