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In neurodegenerative diseases, mitochondria typically serve as the primary and direct source of ROS production during the early stage [52], while NOX acts to amplify pathological signaling pathways, thereby contributing to disease progression
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In studies of different owl species, it was similarly observed that those with higher eumelanin content in their feathers responded better to experimental immune challenges and demonstrated enhanced T-cell and B-cell reponses as compared to their pale counterparts (52, 53, (70)
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