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Transgenic mice expressing FAT-2 (converting MUFAs to n -6 PUFAs) exhibited higher choline and TMAO levels with increased Enterobacteriaceae and depleted Bifidobacteriaceae compared to wild-type and FAT-1 mice (converting n -6 to n -3 PUFAs), suggesting that n -6 PUFA effects on TMAO depend on the n -6/ n -3 ratio [90]
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