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Cagrilintide is a synthetic 37-amino-acid acylated analog of the pancreatic hormone amylin, built on a pramlintide-like backbone with amino-acid substitutions and an N-terminal fatty-diacid (C20) modification via a gamma-glutamic acid linker
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Whereas amylin acts via the amylin receptor, a complex of CALCR and one of three receptor activity modifying proteins (RAMP1–3), cagrilintide binds the amylin receptor and CALCR with similar potency
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