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Previous work by this same group identified a mechanism by which local TNF drives free cholesterol-mediated podocyte injury, independent of circulating TNF, tumor necrosis factor receptor (TNFR)1, or TNFR2 levels
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In the model groups which used erastin and RSL3 to induce ferroptosis, the mRNA expression level of ACSL4 increased significantly and the mRNA expression level of GPX4 decreased significantly compared with the control
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